Mitochondrial content and oxidative damage in full-term placentas from SGA, LGA and AGA infants pregnant women

Introduction The aim was to determine the mitochondrial content, oxidative and nitrosative status in placentas from pregnant women who delivery newborns with alteration of intrauterine growth. Material methods Placentas were selected because classified as small for gestational age (SGA, lowest 10th percentile; n = 9), appropriate (AGA; 9) large (LGA, tallest 90th 9). In placenta tissue status, content determined. Results Lipid peroxidation (TBARS) levels higher LGA compared SGA placentas, but not AGA placentas. Carbonyl 3-nitrotyrosine (3-NT)/actin ratio than Moreover, did have cytochrome oxidase (COX4)/actin AMP–activated protein kinase alpha (AMPK/actin significantly lower LGA. With respect adenosine triphosphatase (ATPase) activity, this SGA. Conclusions oxidized lipid levels, whereas damage placentas; present data also suggest that is